On-demand security and QoS optimization in mobile ad hoc networks

Scope and Method of Study: Security often comes with overhead that will impact link Quality of Service (QoS) performance. In this dissertation, we propose an on-demand security and QoS optimization architecture in mobile ad hoc networks that automatically adapts network security level to changes in network topology, traffic condition, and link QoS requirements, so as to keep the security and QoS at optimum conditions. In order to achieve the overall objective, we introduce three basic frameworks: a policy based plug-in security framework, a multi-layer QoS guided routing algorithm, and a Proportional Integral Derivative (PID) feedback control based security and QoS optimization framework. The research has been evaluated with the network simulator ns-2. Finally, we propose an attack tree and state machine based security evaluation mechanism for ad hoc networks: a new security measurement metric.Findings and Conclusions: Simulations have been done for small and large network sizes, low and high communication ratios, as well as low and high mobility scenarios. The simulations show that the proposed on-demand security and QoS optimization architecture can produce similar performance to non-secure QoS routing protocol under various traffic loads. It provides more secure ad hoc networks without compromising the QoS performance, especially under light and medium traffic conditions

Trust model for certificate revocation in Ad hoc networks

In this paper we propose a distributed trust model for certificate revocation in Adhoc networks. The proposed model allows trust to be built over time as the number of interactions between nodes increase. Furthermore, trust in a node is defined not only in terms of its potential for maliciousness, but also in terms of the quality of the service it provides. Trust in nodes where there is little or no history of interactions is determined by recommendations from other nodes. If the nodes in the network are selfish, trust is obtained by an exchange of portfolios. Bayesian networks form the underlying basis for this model

Profile-based Maximum Penalised Likelihood Trajectory Estimation from Space-borne LOS Measurements

Estimating the boost-phase trajectory of a ballistic missile using line of sight measurements from space-borne passive sensors is an important issue in missile defense. A well-known difficulty of this issue is the poor-observability of the target motion. A profile-based maximum penalised likelihood estimator is presented, which is expected to work in poor-observability scenarios. Firstly, a more adaptable boost-phase profile is proposed by introducing unknown parameters. Then, the estimator is given based on the Bayesian paradigm. After that, a special penalty for box constraint is constructed based on a mixed distribution. Numerical results for some typical scenarios and sensitivity with respect to a priori information are reported to show that the proposed estimator is promising

Exploring the optimal impact force for chronic skeletal muscle injury induced by drop-mass technique in rats

Introduction: Skeletal muscle injuries are widespread in sports, traffic accidents and natural disasters and some of them with poor prognoses can lead to chronic skeletal muscle damage in the clinic. We induced a chronic skeletal muscle injury by controlling time and contusion force using an acute blunt trauma model that will help us better comprehend the pathological features of chronic skeletal muscle injury.Methods: Several levels of injury were induced by repeatedly striking in 5, 10, and 15 times the gastrocnemius muscle from the same height with 200 g weights. After injury, the markers of muscle injury were assessed at 2 and 4 weeks by serum elisa. Electron microscopy, histologic and immunohistochemical staining, and mRNA analysis were used to evaluate the ultrastructure, inflammation, extracellular matrix decomposition, and anabolism of injured muscle in 2 and 4 weeks.Results: All three different kinetic energies can result in skeletal muscle injuries. However, the injured skeletal muscles of rats in each group could not recover within 2 weeks. After 4 weeks, tissue self-repair and reconstruction caused the damage induced by 5 J kinetic energy to almost return to normal. In contrast, damage induced by 10 J kinetic energy displayed slight improvement compared to that at 2 weeks. Despite this, collagen fibers on the surface of the tissue were disorganized, directionally ambiguous, and intertwined with each other. Myofilaments within the tissue were also arranged disorderly, with blurry and broken Z-lines. Damage caused by 15 J kinetic energy was the most severe and displayed no improvements at 4 weeks compared to 2 weeks. At 4 weeks, IL-1β, IL-6, Collagen I, and Collagen III, MMP2 expressions in the 10 J group were lower than those at 2 weeks, showing a tendency towards injury stabilization.Conclusion: After 4 weeks of remodeling and repair, the acute skeletal muscle injury model induced by 10 J kinetic energy can stabilize pathological manifestations, inflammatory expression, and extracellular matrix synthesis and catabolism, making it an appropriate model for studying chronic skeletal muscle injuries caused by acute injury

Assessing the Effectiveness of In-Vehicle Highway Back-of-Queue Alerting System

This paper proposes an in-vehicle back-of-queue alerting system that is able to issue alerting messages to drivers on highways approaching traffic queues. A prototype system was implemented to deliver the in-vehicle alerting messages to drivers via an Android-based smartphone app. To assess its effectiveness, a set of test scenarios were designed and implemented on a state-of-the-art driving simulator. Subjects were recruited and their testing data was collected under two driver states (normal and distracted) and three alert types (no alerts, roadside alerts, and in-vehicle auditory alerts). The effectiveness was evaluated using three parameters of interest: 1) the minimum Time-to-Collision (mTTC), 2) the maximum deceleration, and 3) the maximum lateral acceleration. Statistical models were utilized to examine the usefulness and benefits of each alerting type. The results show that the in-vehicle auditory alert is the most effective way for delivering alerting messages to drivers. More specifically, it significantly increases the mTTC (30% longer than that of 'no warning') and decreases the maximum lateral acceleration (60% less than that of 'no warning'), which provides drivers with more reaction time and improves driving stability of their vehicles. The effects of driver distraction significantly decrease the efficiency of roadside traffic sign alert. More specifically, when the driver is distracted, the roadside traffic sign alert performs significantly worse in terms of mTTC compared with that of normal driving. This highlights the importance of the in-vehicle auditory alert when the driver is distracted

Human RECQL5β stimulates flap endonuclease 1

Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not been linked to any human disorder yet; cells devoid of RECQL1 and RECQL5 display increased chromosomal instability. Here, we report the physical and functional interaction of the large isomer of RECQL5, RECQL5β, with the human flap endonuclease 1, FEN1, which plays a critical role in DNA replication, recombination and repair. RECQL5β dramatically stimulates the rate of FEN1 cleavage of flap DNA substrates. Moreover, we show that RECQL5β and FEN1 interact physically and co-localize in the nucleus in response to DNA damage. Our findings, together with the previous literature on WRN, BLM and RECQL4’s stimulation of FEN1, suggests that the ability of RecQ helicases to stimulate FEN1 may be a general feature of this class of enzymes. This could indicate a common role for the RecQ helicases in the processing of oxidative DNA damage

Limb development genes underlie variation in human fingerprint patterns

Fingerprints are of long-standing practical and cultural interest, but little is known about the mechanisms that underlie their variation. Using genome-wide scans in Han Chinese cohorts, we identified 18 loci associated with fingerprint type across the digits, including a genetic basis for the long-recognized “pattern-block” correlations among the middle three digits. In particular, we identified a variant near EVI1 that alters regulatory activity and established a role for EVI1 in dermatoglyph patterning in mice. Dynamic EVI1 expression during human development supports its role in shaping the limbs and digits, rather than influencing skin patterning directly. Trans-ethnic meta-analysis identified 43 fingerprint-associated loci, with nearby genes being strongly enriched for general limb development pathways. We also found that fingerprint patterns were genetically correlated with hand proportions. Taken together, these findings support the key role of limb development genes in influencing the outcome of fingerprint patterning

Polygenic risk scores for prediction of breast cancer risk in Asian populations.

PURPOSE: Non-European populations are under-represented in genetics studies, hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed to develop PRSs using the largest available studies of Asian ancestry and to assess the transferability of PRS across ethnic subgroups. METHODS: The development data set comprised 138,309 women from 17 case-control studies. PRSs were generated using a clumping and thresholding method, lasso penalized regression, an Empirical Bayes approach, a Bayesian polygenic prediction approach, or linear combinations of multiple PRSs. These PRSs were evaluated in 89,898 women from 3 prospective studies (1592 incident cases). RESULTS: The best performing PRS (genome-wide set of single-nucleotide variations [formerly single-nucleotide polymorphism]) had a hazard ratio per unit SD of 1.62 (95% CI = 1.46-1.80) and an area under the receiver operating curve of 0.635 (95% CI = 0.622-0.649). Combined Asian and European PRSs (333 single-nucleotide variations) had a hazard ratio per SD of 1.53 (95% CI = 1.37-1.71) and an area under the receiver operating curve of 0.621 (95% CI = 0.608-0.635). The distribution of the latter PRS was different across ethnic subgroups, confirming the importance of population-specific calibration for valid estimation of breast cancer risk. CONCLUSION: PRSs developed in this study, from association data from multiple ancestries, can enhance risk stratification for women of Asian ancestry